Routine Venous Thromboembolism Prophylaxis May Be Inadequate in the Hypercoagulable State of Severe Coronavirus Disease 2019

This is an observational study of 109 critically ill Covid-19 patients admitted to the ICU to determine the frequency of venous thromboembolism and the degree of inflammatory and coagulation marker elevation associated with venous thromboembolism. VTE was diagnosed in 31 patients (28%) 8 ± 7 days after hospital admission. Twelve patients (11%) had thromboelastography performed and 58% of these patients had a hypercoagulable study. The calculated coagulation index was hypercoagulable in 50% of patients with thromboelastography. This study confirms that Covid-19 results in a hypercoagulable state and that routine chemical venous thromboembolism prophylaxis may be inadequate in preventing venous thromboembolism in severe Covid-19.